Prey 2

The story of Prey 2 had been narratively tied to the first game. In Prey, an alien spacecraft called the Sphere appears over the southwestern portion of the United States and starts abducting humans and other objects as part of its cycle to sustain its resource supply and its organic crew. One of those abducted is Domasi "Tommy" Tawodi who, in part due to his spirit guide from his Native American background, is able to navigate the Sphere, defeat hostile alien forces, and succeed in freeing captive humans and other lifeforms from the intelligence that controls it, before returning to earth.

S. Marshal Killian Samuels, who starts the game on a passenger flight which suddenly crashes onto the Sphere, shown during the events of Prey. At the end of a short battle with some aliens he is knocked unconscious, after which the plot jumps forward several years. Samuels is now a bounty hunter on the alien world Exodus.

The first Prey game was released in July 2006; it had been developed by Human Head Studios, under contract with 3D Realms, and published by 2K Games. The game was considered successful; it had received Metacritic aggregate scores of 83 and 79 for the Xbox 360 and Microsoft Windows versions, respectively, and by October 2006, over one million units had been sold according to 3D Realms' Scott Miller. Miller announced as early as August 2006 that development on a sequel, Prey 2, had started.

In June 2007, Miller co-founded a brand-management organization Radar Group, which was designed to help fledgling development studios bring their games to publishers and distributors. Prey 2 was one of three titles that Radar Group announced it was backing in March 2008, along with Earth No More and Incarnate. At this point, Prey 2 was described to be a narrative sequel to Prey. In the game, Tommy abandons Earth as he is accused of the disappearance of his family and his girlfriend. At this point in development, Prey 2 would have continued to be a first-person shooter using the portal/gravity-based gameplay as from the original game.

In addition to reporting on the Prey property being transferred to Arkane in May 2015, the website Kotaku had some other incidents in which they had reported on projects from Bethesda through inside information well before they were to be announced publicly. As a result, Bethesda indefinitely blacklisted Kotaku in October 2015, denying the site any pre-release review copies or access to their spokesmen or developers at game conference events or via interview. The 2017 Prey game includes an achievement "Press Sneak", based on reading all the emails within computer terminals in the game, based on this incident.

The team would come full circle after the 2019 closure of Human Head Studios shortly after the release of Rune II with most of the staff moving on to Bethesda-managed Roundhouse Studios.