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S.E.M.I.: Side Effects May Include... cover

2026 · Two Horn Unicorn · Beat 'em up · Indie

S.E.M.I.: Side Effects May Include...

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.

Released
23 January 2026
Platforms
Windows
Genres
Beat 'em upIndieArcade
Developers
Two Horn Unicorn
Publishers
Two Horn Unicorn
Modes
Co-opMultiplayerSingle-player
Perspective
Third person
Themes
ActionComedyParty
Engine
Unreal Engine 5
Age ratings
ESRB E10+PEGI 12CERO BGRAC 12+USK 12CLASS_IND 12ACB PG
Languages
Chinese (Simplified), Dutch, English, English (UK), French, German, Japanese, Portuguese (Brazil), Russian, Spanish (Spain)
›Story

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.

Keywords

  • physics
  • funny
  • physics puzzles
  • puzzle platformer
  • ragdoll physics
  • action combat
  • logic puzzle
  • escape game
  • crazy
  • online coop
  • action roguelike
  • action platformer

Media

S.E.M.I.: Side Effects May Include... screenshot 1

Releases by platformdates and regions as published

PlatformReleasedRegions
WindowsEarly Access20 November 2025Worldwide · Worldwide 23 January 2026

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