Dr. Mario Express

Dr. Mario Express is a falling block tile-matching video game. The player is given a playing field, seen in the Nintendo DSi's bottom screen, populated with viruses of three colors: red, blue, and yellow. Mario, who has assumed the role of a doctor, drops two-colored medicinal capsules into the playing field.

The player manipulates these capsules as they fall, moving them left or right and rotating them such that they become aligned alongside viruses of matching colors. When four capsule halves and viruses of matching color are joined together in a straight line, they are removed from play. The main objective of the game therefore is to remove all the viruses from the playing field without letting the capsules themselves pile up and obstruct the opening into the field. Successive levels increase the initial number of viruses to clear.

Dr. 33% and 76 on GameRankings and Metacritic. Critics generally praised the gameplay but lamented the lack of the multiplayer mode offered in earlier Dr. Mario games.

NintendoLife awarded the game a score of 8 out of 10, applauding the "addictive" gameplay and calling it a "welcome addition to [the] DSiWare library." It noted, however, that "the omission of a multiplayer mode is likely to rub some longtime fans of the game the wrong way." 5 out of 10, stating the single-player experience is "solid" but "the lack of multiplayer hinders its lifespan." Pocket Gamer awarded Dr.