Run Saber

After choosing either the male character, Allen, or the female character, Sheena, the player is sent to five different levels around a fantastical Earth. Sheena has an ice affinity, while Allen has a lightning one. A third Saber, Kurtz, is aligned with fire, and is an enemy the player must fight several times.

The players can use a slash attack (the standard attack) which Allen does forward and Sheena upward, use a mid-air kick, or use the Hyper Bomb (special pick up item). The players can also climb up and down walls and hang onto the ceiling. There is a power jump similar to the Screw Attack of Super Metroid.

Years into the future after Earth has been overly polluted and resources are running low, a scientist quickly comes up with a solution: a new chemical that will reverse the effects of pollution. As colonists settle in space to avoid the pollution, the newfound chemical is quickly launched in a missile into the atmosphere where it explodes and releases the chemical, which begins to horribly mutate any and all humans infected with it. The scientist knew the effects of his chemical and uses the mutated people as his soldiers to rule the Earth.

Humanity's only hope is a new weapon known as Project Saber, three cyborgs that are genetically enhanced to supernatural levels. Kurtz, the first Saber, malfunctions and escapes to Earth before the project is complete. The remaining Sabers, Allen and Sheena, are dispatched to eliminate the scientist and his militant mutant threat, and to neutralize Kurtz if possible.

Originally, the boss at the end of the Tong City level was supposed to be a woman lying on her side, but Nintendo felt that this violated their content guidelines as they did not want to depict or reference violence against women on their hardware, so the woman was changed into a dead woman and was approved.

Run Saber received average reviews.

Initial reviewers compared Run Saber to the Capcom arcade game Strider, noting that this is the only "Strider-style" game on the Super Nintendo Entertainment System.