Aliens: Infestation

Gameplay of Aliens: Infestation is comparable to the Metroid video games, where players are encouraged to search and backtrack for weapons, upgrades, and keys. S. Sulaco as well as LV-426 and Phobos in order to investigate the Union of Progressive Peoples (UPP) and Weyland-Yutani's involvement in Xenomorph development. The game incorporates a permadeath mechanic.

If a marine falls in battle, another in the party will take their place. The player loses if the entire party is wiped out. Fallen characters can be replaced with any of fifteen displaced marines found throughout the game, each with their own unique dialogue.

The USS Sephora has discovered the USS Sulaco adrift in space after the events of Aliens and Alien 3. The Colonial Marines are sent aboard the Sulaco to investigate and recover the life form detected aboard the ship.

Aliens: Infestation was developed simultaneously with Aliens: Colonial Marines, releasing ahead of Marines' completion. Because Gearbox Software was busy developing Colonial Marines for PC and home consoles, they chose to delegate the development of a Nintendo DS tie-in to another studio. Gearbox chose to contact WayForward because of the latter company's experience in developing the science-fiction action game Contra 4. Gearbox, Sega, and 20th Century Fox accepted WayForward's initial concept for the game.

When doing their research, game director Adam Tierney focused heavily on Ridley Scott's Alien and James Cameron's Aliens as inspiration. WayForward hired comic book artist Chris Bachalo to design and illustrate the game's characters; some of Bachalo's temporary names for these characters remain in the final game. To capture the films' slasher appeal, while still keeping the player emotionally invested, the development team created 20 unique characters, with the game's dialogue re-written 20 times, to make sure it offered the biggest 'gut-punch' when one dies. In conjunction with the game's 'party of four' mechanic, the developers wanted players to grow attached to their favorites, which, in-turn, increased the likelihood of getting one killed. The game's difficulty was balanced so that the player would lose unique characters at roughly the same rate they are introduced.

Aliens: Infestation received "generally favorable reviews" according to the review aggregation website Metacritic.

Digital Spy gave it four stars out of five, saying, "In many ways, it feels like the Aliens game we should have been given back in the 16-bit era when the movie series was still relatively new. Whether it has been worth the wait is debatable, but this is certainly a worthy addition to the DS library." However, The Digital Fix gave it seven out of ten, saying that "It can be uneven at times in terms of quality but it is highly enjoyable, especially if you are fan of either the franchise or even if you are just a fan of 'Metroidvania' games."