Mighty Switch Force! 2

Gameplay follows a similar premise to the previous game in which players assume the role of Patricia Wagon, who is now a firefighter that must rescue the Hooligan Sisters of the last game from blazing fires. Like the previous game, players are tasked with using Patricia's ability to push blocks in and out of the foreground in order to rescue the Hooligan Sisters and reach the extraction point as quickly as possible. This time around, Patricia's blaster from the previous game has been replaced by a new dousing apparatus that shoots a spray of water, which can be used to defeat enemies and put out fires. This new mechanic adds various new types of blocks to the mix, such as mud blocks that must be dissolved with water, pipe blocks that redirect the spray of water and wooden blocks that must be burned in order to destroy. Along with par times that the player may attempt to beat, each level also contains a hidden "U.S.B" baby they may try to locate.

The "Galactic Fire Brigade" issues a code red: Tangent City is spontaneously combusting and everything is catching ablaze. Patrica "Patty" Wagon must help as a firefighter, using the issued Infinity Dousing Apparatus, and rescue the Hooligan Sisters, who have been reformed since their capture, and are stuck in the infernos within Tangent City. At the same time, HQ has picked up cries of a distressed infant dubbed the "Ugly Secret Baby", or, "U.S.B". The "Rapid Sparkle Transmission System" usually used to extrapolate people was made for use on adults, so Patty must find an alternative transport means (she achieves this by kicking the babies off screen, in-game).

Patty travels across Tangent City and rescues the Hooligan Sisters while tackling fires. Eventually Patty reaches the cause of the fires, a giant dragon creature, which has now swallowed the Hooligan Sisters. Patty defeats the dragon, rescuing the Hooligan Sisters, and restoring peace.

Mighty Switch Force! 2 received "average" reviews on both platforms according to the review aggregation website Metacritic. Destructoid praised the gameplay of the 3DS version but lamented its short length, a fault shared by the game's predecessor.

In 2020, the main vocal theme of Mighty Switch Force! 2, "Rescue Girl", gained attention beyond the niche of Mighty Switch Force! after it was used in a viral video meme called "May 2020" that mocked the idea that 2020 could not 'get any worse' with the hypothetical return of a dancing Adolf Hitler.