Resident Evil 6

Resident Evil 6 allows players to select between four scenarios with interwoven storylines centered on Division of Security Operations (DSO) agent Leon S. Kennedy, Bioterrorism Security Assessment Alliance (BSAA) Captain Chris Redfield, mercenary Jake Muller and spy Ada Wong.

In the Leon, Chris and Jake scenarios, players have the option of controlling either them or their respective partners, United States Secret Service agent Helena Harper, BSAA sniper Piers Nivans and DSO agent Sherry Birkin. The character not selected by the player is controlled by either artificial intelligence (AI) or another player via local or online multiplayer. Ada's scenario can be played with or without a partner and a second player who joins will control the non-canonical character Agent. In addition, each scenario features a different play-style; for example, some player-characters are more vulnerable to attacks whereas others are more resilient.

On 24 December 2012, mercenary Jake Muller (Troy Baker / Daisuke Namikawa) is fighting in a civil war within the Eastern European country of Edonia when his employers, the Edonian Liberation Army, unknowingly turn themselves into intelligent and adaptive bio-weapons known as J'avo after using injections supplied by the bio-terrorist group Neo-Umbrella. Jake is unaffected, and during his escape from the berserking rebels partners with Division of Security Operations (DSO) agent and Raccoon City survivor Sherry Birkin (Eden Riegel / Maaya Sakamoto), learning that she is to extract him from the country to create a vaccine for the newly emerged C-virus; Jake accepts on the promise of a lucrative payout. However, they are relentlessly hunted by Ustanak, a hulking bio-weapon. Meanwhile, the Bio-terrorism Security Assessment Alliance (BSAA) intervenes in the conflict, leading to a strike team led by Chris Redfield (Roger Craig Smith / Hiroki Tōchi) and Piers Nivans (Christopher Emerson / Shuhei Sakaguchi) being deployed to eliminate the rampaging J'avo.

After briefly being assisted by Jake and Sherry, who are soon after extracted by helicopter, they are attacked by the leader of Neo-Umbrella, who claims to be Ada Wong (Courtenay Taylor / Junko Minagawa); she kills the entire team, except Chris and Piers, using a device that injects them with the C-virus, turning them into J'avo. Chris goes into a self-imposed exile, afflicted with post-traumatic amnesia. Meanwhile, Sherry and Jake's helicopter is attacked by Ustanak, forcing them to crash land into the mountains where they are captured by Neo-Umbrella and experimented on for six months, during which Jake learns that he is the son of late bio-terrorist Albert Wesker.

Resident Evil 6 was conceptualized soon after the release of Resident Evil 5, and entered full development in 2009. Resident Evil 5 producer Jun Takeuchi said that he considered a "completely new system" for Resident Evil 6, but ruled out his involvement. In March 2009, co-producer Masachika Kawata stated that the new installment was not decided upon, but admitted that it could take Capcom four to eight years to develop. Kawata later claimed that the new game will be drastically different from its predecessors.

The game was directed by Eiichiro Sasaki, who also directed the Resident Evil Outbreak series. When development of the game first begun, producer Yoshiaki Hirabayashi wanted to revolve the game around the "ultimate horror entertainment", bearing in mind that the team considered the upcoming Resident Evil 6 to be the flagship title of the horror genre. In a February 2012 interview, Hirabayashi stated that he went to lengths to balance "all of the things people love" about the series, so the team focused to orientate gameplay around horror themes. Each of the four campaigns was designed around a different expression of horror: Leon's story reflecting "gothic, classic Resident Evil-style horror", Chris' story "a horror of the battlefield", Jake's story involving the fear of being stalked, and Ada's story being "a very classic Resident Evil-style" experience.

According to review aggregator website Metacritic, Resident Evil 6 received "mixed or average" reviews. The website described the game as "the first game in the main series that failed to receive a positive reception from game critics" and reported that the critics "complained about bloat and inconsistency", and felt that "RE6 was more generic shooter than distinctive survival horror game."

Critics praised the graphics, AI and controls. A reviewer from Game Informer stated that the game did not "hold back" the decadent experience from being an "unhinged flaming rollercoaster ride". A reviewer from the Official Xbox Magazine concluded that the game was an accomplished shooter, and a fittingly "thunderous" send-off for Resident Evil, while also praising the length and variety of the game. GameTrailers noted the shift away from the style and tone of past games in the series, yet still praised the overall direction, stating that despite the "old identity stripped away", the game presented itself as a "massive" action game.